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MessagePosté le: Sam 21 Mai - 03:37 (2016)    Sujet du message: Mitochondria In Health And Disease || Répondre en citant




Mitochondria In Health And Disease || > urlin.us/2bz5s





You,,need,,to,,reset,,your,,browser,,to,,accept,,cookies,,or,,to,,ask,,you,,if,,you,,want,,to,,accept,,cookiesMechanisms,,of,,mitochondrial,,radical,,generation,,,targets,,of,,oxidative,,injury,,and,,the,,potential,,role,,of,,uncoupling,,proteins,,as,,regulators,,of,,radical,,generation,,are,,discussedTaanman,,,Mitochondrial,,,Diseases,,,in,,,Growth,,,and,,,Development,,,,J.MThey,,,contain,,,a,,,high,,,concentration,,,of,,,glutathione,,,,a,,,variant,,,of,,,superoxide,,,dismutase,,,,and,,,catalase,,,to,,,remove,,,the,,,potentially,,,harmful,,,peroxide,,,that,,,is,,,produced,,,by,,,superoxide,,,dismutase.The,,,specific,,,sites,,,of,,,free,,,radical,,,generation,,,along,,,the,,,electron,,,transport,,,chain,,,are,,,controversialBelow,are,the,most,common,reasons:In,brief,,we,found,no,evidence,for,a,role,of,ROS,in,glutamate-induced,mitochondrial,depolarization,(40),,and,in,fact,we,suggest,that,many,of,the,protective,effects,of,antioxidants,in,this,model,have,nothing,to,do,with,ROS,generation,but,rather,with,the,redox,modulation,of,the,NMDA,glutamate,receptor,,which,is,altered,directly,by,the,antioxidants,,therefore,reducing,the,calcium,load,(40,41)That,,pore,,opening,,normally,,plays,,a,,role,,in,,other,,forms,,of,,coordinated,,programmed,,cell,,death,,seems,,unlikely,,,because,,in,,many,,cases,,of,,apoptosis,,,mitochondrial,,membrane,,potential,,can,,be,,maintained,,,at,,least,,through,,the,,early,,phases,,of,,the,,process,,,and,,maintenance,,of,,potential,,in,,the,,face,,of,,pore,,opening,,is,,most,,unlikely,,(25).The,,most,,effective,,mechanism,,to,,open,,the,,mPTP,,is,,to,,expose,,mitochondria,,to,,a,,combination,,of,,high,,matrix,,calcium,,together,,with,,a,,pro-oxidantTable,,,of,,,Contents,,,Preface,,,,C.DIn,this,review,,I,consider,recent,developments,in,our,knowledge,of,basic,aspects,of,mitochondrial,biology,as,an,essential,step,in,developing,our,understanding,of,the,contributions,of,mitochondria,to,diseaseInhibition,of,respiration,distal,to,the,point,of,radical,generation,(e.g.,,at,complex,IV,with,cyanide),is,expected,to,increase,ROS,production,,whereas,uncouplers,will,tend,to,reduce,electron,leakage,by,increasing,the,respiratory,rate,,favoring,the,transfer,of,electrons,to,oxygen,at,complex,IV,and,generating,waterPlease,review,our,privacy,policyIn,a,second,model,,of,calcium,overload,in,neurons,,the,neurotoxicity,of,glutamate,depends,on,mitochondrial,calcium,uptake,,but,the,toxicity,to,mitochondria,also,requires,the,generation,of,nitric,oxideAlready,,,read,,,this,,,title?,,,Complete,,,the,,,CPD,,,form,,,,,,View,,,our,,,entire,,,list,,,of,,,CPD,,,Certified,,,titles,,,,,,Close,,,Close,,,CHOICE,,,,,,Outstanding,,,Academic,,,Title,,,,,,Award,,,Winner,,,Close,,,Close,,,Shingo,,,Research,,,and,,,Professional,,,Publication,,,Award,,,Winner,,,Close,,,About,,,98%,,,of,,,inhaled,,,oxygen,,,is,,,consumed,,,by,,,mitochondria,,,,and,,,without,,,mitochondria,,,,we,,,would,,,have,,,no,,,need,,,of,,,the,,,oxygen,,,transfer,,,machinery,,,of,,,the,,,lungs,,,,red,,,cells,,,,hemoglobin,,,,or,,,even,,,the,,,circulatory,,,system,,,that,,,delivers,,,oxygen,,,to,,,the,,,tissuesWallis,,,And,,,Futuna,,,Western,,,Sahara,,,Yemen,,,Zambia,,,Zimbabwe,,,land,,,Islands,,,This,,,will,,,help,,,us,,,determine,,,what,,,currency,,,and,,,product,,,offerings,,,to,,,displayOne,,,fascinating,,,phenomenon,,,is,,,that,,,of,,,ischemic,,,preconditioningWarning:,,,The,,,NCBI,,,web,,,site,,,requires,,,JavaScript,,,to,,,functionJ,Cell,Biol145,:795,808,1999OpenUrlAbstract/FREE,Full,TextParekh,AB:,Store-operated,Ca2+,entry:,dynamic,interplay,between,endoplasmic,reticulum,,mitochondria,and,plasma,membraneClose,,What,,is,,VitalSource?,,CRC,,Press,,eBooks,,are,,available,,through,,VitalSourceThe,,,calcium,,,increase,,,mediated,,,by,,,NMDA,,,receptor,,,activation,,,is,,,thus,,,associated,,,with,,,nitric,,,oxide,,,generation,,,,and,,,the,,,combination,,,leads,,,to,,,the,,,collapse,,,of,,,mitochondrial,,,membrane,,,potential,,,followed,,,by,,,cell,,,death.PMID:,,,14749273,,,[PubMed,,,-,,,indexed,,,for,,,MEDLINE],,,Free,,,full,,,textSharePublication,,,Types,,,,MeSH,,,Terms,,,,SubstancesPublication,,,TypesResearch,,,Support,,,,Non-U.SThe,,molecular,,identity,,of,,the,,uniporter,,remains,,to,,be,,establishedPlease,,,Select,,,Your,,,Country,,,--,,,Select,,,one,,,--,,,Afghanistan,,,Albania,,,Algeria,,,American,,,Samoa,,,Andorra,,,Anguilla,,,Angola,,,Antarctica,,,Antigua,,,And,,,Barbuda,,,Argentina,,,Armenia,,,Aruba,,,Austria,,,Australia,,,Azerbaijan,,,Bahamas,,,Bahrain,,,Bangladesh,,,Barbados,,,Belize,,,Belgium,,,Belarus,,,Benin,,,Bermuda,,,Bhutan,,,Bolivia,,,Bosnia,,,And,,,Herzegovina,,,Botswana,,,Bouvet,,,Island,,,Brazil,,,British,,,Indian,,,Ocean,,,Territory,,,Brunei,,,Darussalam,,,Bulgaria,,,Burundi,,,Burkina,,,Faso,,,Cambodia,,,Cameroon,,,Canada,,,Cape,,,Verde,,,Cayman,,,Islands,,,Central,,,African,,,Republic,,,Chad,,,Chile,,,China,,,Christmas,,,Island,,,Cocos,,,(Keeling),,,Islands,,,Colombia,,,Comoros,,,Congo,,,,The,,,Democratic,,,Republic,,,Of,,,The,,,Congo,,,Cook,,,Islands,,,Costa,,,Rica,,,Croatia,,,Cyprus,,,Czech,,,Republic,,,Cte,,,D'ivoire,,,Denmark,,,Djibouti,,,Dominican,,,Republic,,,Dominica,,,Ecuador,,,Egypt,,,El,,,Salvador,,,Equatorial,,,Guinea,,,Eritrea,,,Estonia,,,Ethiopia,,,Falkland,,,Islands,,,(Malvinas),,,Faroe,,,Islands,,,Fiji,,,Finland,,,France,,,French,,,Southern,,,Territories,,,French,,,Polynesia,,,French,,,Guiana,,,Gabon,,,Gambia,,,Georgia,,,Germany,,,Ghana,,,Gibraltar,,,Grenada,,,Greenland,,,Greece,,,Guam,,,Guatemala,,,Guadeloupe,,,Guernsey,,,Guinea-Bissau,,,Guinea,,,Guyana,,,Haiti,,,Heard,,,Island,,,And,,,Mcdonald,,,Islands,,,Holy,,,See,,,(Vatican,,,City,,,State),,,Hong,,,Kong,,,Honduras,,,Hungary,,,Iceland,,,India,,,Indonesia,,,Iraq,,,Ireland,,,Isle,,,Of,,,Man,,,Israel,,,Italy,,,Jamaica,,,Japan,,,Jersey,,,Jordan,,,Kazakhstan,,,Kenya,,,Kiribati,,,Korea,,,,Republic,,,Of,,,Kuwait,,,Kyrgyzstan,,,Lao,,,People's,,,Democratic,,,Republic,,,Latvia,,,Lebanon,,,Lesotho,,,Liberia,,,Libyan,,,Arab,,,Jamahiriya,,,Liechtenstein,,,Lithuania,,,Luxembourg,,,Macedonia,,,,The,,,Former,,,Yugoslav,,,Republic,,,Of,,,Macao,,,Madagascar,,,Mali,,,Malta,,,Maldives,,,Malaysia,,,Malawi,,,Martinique,,,Marshall,,,Islands,,,Mauritania,,,Mauritius,,,Mayotte,,,Mexico,,,Micronesia,,,,Federated,,,States,,,Of,,,Moldova,,,,Republic,,,Of,,,Montserrat,,,Montenegro,,,Monaco,,,Mongolia,,,Morocco,,,Mozambique,,,Myanmar,,,Namibia,,,Nauru,,,Nepal,,,Netherlands,,,Netherlands,,,Antilles,,,New,,,Zealand,,,New,,,Caledonia,,,Nicaragua,,,Nigeria,,,Niger,,,Niue,,,Norway,,,Northern,,,Mariana,,,Islands,,,Norfolk,,,Island,,,Oman,,,Pakistan,,,Palau,,,Palestinian,,,Territory,,,,Occupied,,,Panama,,,Papua,,,New,,,Guinea,,,Paraguay,,,Peru,,,Philippines,,,Pitcairn,,,Poland,,,Portugal,,,Qatar,,,Reunion,,,Romania,,,Russian,,,Federation,,,Rwanda,,,Saint,,,Martin,,,Saint,,,Pierre,,,And,,,Miquelon,,,Saint,,,Vincent,,,And,,,The,,,Grenadines,,,Saint,,,Lucia,,,Saint,,,Barthlemy,,,Saint,,,Kitts,,,And,,,Nevis,,,Saint,,,Helena,,,Samoa,,,San,,,Marino,,,Sao,,,Tome,,,And,,,Principe,,,Saudi,,,Arabia,,,Senegal,,,Serbia,,,Seychelles,,,Sierra,,,Leone,,,Singapore,,,Slovakia,,,Slovenia,,,Solomon,,,Islands,,,Somalia,,,South,,,Georgia,,,And,,,The,,,South,,,Sandwich,,,Islands,,,South,,,Africa,,,Spain,,,Sri,,,Lanka,,,Suriname,,,Svalbard,,,And,,,Jan,,,Mayen,,,Swaziland,,,Sweden,,,Switzerland,,,Taiwan,,,Tajikistan,,,Tanzania,,,,United,,,Republic,,,Of,,,Thailand,,,Timor-Leste,,,Togo,,,Tokelau,,,Tonga,,,Trinidad,,,And,,,Tobago,,,Tunisia,,,Turkmenistan,,,Turks,,,And,,,Caicos,,,Islands,,,Turkey,,,Tuvalu,,,Uganda,,,Ukraine,,,United,,,States,,,Minor,,,Outlying,,,Islands,,,United,,,States,,,United,,,Kingdom,,,United,,,Arab,,,Emirates,,,Uruguay,,,Uzbekistan,,,Vanuatu,,,Venezuela,,,Viet,,,Nam,,,Virgin,,,Islands,,,,British,,,Virgin,,,Islands,,,,U.SThis,,leads,,to,,increased,,ROS,,generation,,,and,,the,,superoxide,,that,,is,,the,,major,,species,,formed,,may,,in,,turn,,react,,with,,the,,NO,,,producing,,the,,more,,aggressively,,reactive,,peroxynitrite128,,131,,2007,Share,this,Title,Recommend,to,Librarian,Related,Titles,1,of,3,Genomics,and,Proteomics,in,Nutrition,Organelles,,Genomes,and,Eukaryote,Phylogeny:,An,Evolutionary,Synthesis,in,the,Age,of,Genomics,Mitochondrial,Medicine,Recommended,For,You,,View,Cart,Close,Mitochondria,in,Health,and,Disease,ISBN,Quantity:,Shopping,Cart,Summary,Items,Subtotal,View,Cart,Continue,Shopping,Customers,also,boughtOur,,recent,,data,,show,,that,,when,,we,,use,,the,,model,,described,,above,,,with,,a,,standardized,,set,,of,,illumination,,conditions,,,the,,mPTP,,will,,open,,in,,cardiomyocytes,,after,,a,,remarkably,,reproducible,,time,,period,,(20,,min)Transfecting,,,cells,,,with,,,fluorescent-tagged,,,proteins,,,to,,,study,,,their,,,distribution,,,or,,,their,,,redistribution,,,with,,,stimulation,,,has,,,also,,,proven,,,extremely,,,instructiveor,,its,,licensors,,or,,contributorsIt,,,behaves,,,apparently,,,more,,,like,,,a,,,channel,,,than,,,like,,,a,,,carrier,,,and,,,is,,,blocked,,,by,,,ruthenium,,,red,,,,which,,,blocks,,,many,,,classes,,,of,,,calcium-permeant,,,channelsThe,,,free,,,VitalSource,,,Bookshelf,,,application,,,allows,,,you,,,to,,,access,,,to,,,your,,,eBooks,,,whenever,,,and,,,wherever,,,you,,,chooseIn,this,review,,I,consider,recent,developments,in,our,knowledge,of,basic,aspects,of,mitochondrial,biology,as,an,essential,step,in,developing,our,understanding,of,the,contributions,of,mitochondria,to,diseaseWe,have,explored,the,system,in,some,detail,in,two,cell,types:,an,excitable,cell,,the,cardiomyocyte,(31),,and,a,nonexcitable,cell,,the,cortical,astrocyte,(30)Most,,likely,,,the,,drugs,,act,,to,,inhibit,,complex,,II,,and,,increase,,free,,radical,,generation,,,and,,perhaps,,this,,upregulates,,intrinsic,,antioxidant,,mechanisms,,,limiting,,the,,damage,,induced,,by,,a,,second,,period,,of,,oxidative,,stress.It,,seems,,that,,this,,model,,may,,be,,widely,,applicable,,to,,understanding,,the,,cell,,injury,,that,,develops,,after,,damage,,to,,the,,respiratory,,chain,,and,,the,,resultant,,increase,,in,,ROS,,generation,,and,,oxidative,,stress2004,,,Aug;25(4):365-451.Mitochondria,,,in,,,health,,,and,,,disease:,,,perspectives,,,on,,,a,,,new,,,mitochondrial,,,biology.Duchen,,,MR1.Author,,,information1Department,,,of,,,Physiology,,,and,,,Mitochondrial,,,Biology,,,Group,,,,University,,,College,,,London,,,,Gower,,,Street,,,,London,,,WC1E,,,6BT,,,,UKThis,,is,,a,,large,,conductance,,pathway,,in,,the,,inner,,mitochondrial,,membrane,,,probably,,generated,,by,,an,,alteration,,in,,the,,conformation,,of,,membrane,,proteins,,that,,normally,,perform,,other,,rolesthe,,ANT,,and,,possibly,,the,,voltage-dependent,,anion,,channel,,,which,,is,,sited,,in,,the,,outer,,membraneWhat,,perhaps,,surprised,,us,,most,,was,,that,,the,,transient,,openings,,of,,the,,mPTP,,appear,,to,,be,,completely,,innocuous,,and,,cause,,no,,evident,,harm,,to,,the,,cell,,,with,,no,,sign,,of,,apoptosis,,or,,cytochrome,,c,,release,,in,,illuminated,,cells,,even,,24,,h,,later,,(30).We,,have,,wondered,,to,,what,,extent,,this,,system,,represents,,a,,model,,for,,the,,events,,at,,the,,reperfusion,,of,,anoxic,,or,,ischemic,,tissue,,,in,,which,,ATP,,is,,depleted,,,ROS,,generation,,is,,high,,,and,,intramitochondrial,,calcium,,content,,is,,high,,,as,,discussed,,aboveThis,site,stores,nothing,other,than,an,automatically,generated,session,ID,in,the,cookie;,no,other,information,is,capturedRoles,,,of,,,Mitochondria,,,in,,,Health,,,and,,,Disease,,,healthcare,,practitioner,,visitor,,or,,subscriber,,to,,the,,website,,student,,or,,faculty,,member,,researcher,,or,,librarian,,These,,include,,the,,role,,of,,mitochondrial,,and,,peroxisome,,group,,VIB,,phospholipase,,A2,,(iPLA2g),,in,,β-cell,,proliferation,,and,,redox,,control,,(Bao,,et,,al.,,,2013),,,the,,study,,of,,mitochondrial,,metabolic,,and,,structural,,phenotypes,,in,,liver,,and,,skeletal,,muscle,,from,,obese,,animals,,(Cao,,et,,al.,,,2013),,,the,,modulator,,effects,,of,,hydrogen,,disulfide,,in,,neuronal,,cells,,and,,mitochondria,,(Guo,,et,,al.,,,2013),,,the,,mechanisms,,by,,which,,astragaloside,,IV,,protects,,against,,oxidative,,stress-induced,,increased,,permeability,,transition,,pore,,opening,,in,,cardiac,,cell,,line,,(He,,et,,al.,,,2012),,,the,,effects,,of,,alpha-lipoic,,acid,,on,,mitochondrial,,superoxide,,and,,glucocorticoid-induced,,hypertension,,(Ong,,et,,al.,,,2013),,,and,,the,,development,,of,,in,,vitro,,approaches,,to,,study,,population,,mitochondrial,,genomic,,variations,,(Lin,,et,,al.,,,2013) 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